ATP and the Heart, 1st Edition by Joanne S. Ingwall Ph.D. (auth.)

By Joanne S. Ingwall Ph.D. (auth.)

ATP performs a imperative position within the major factors of cardiac morbidity and mortality within the western international: ischemia and middle failure. we're in our infancy utilizing what's recognized approximately biology and chemistry of ATP towards constructing powerful cures for those ailments. during this quantity, the present knowing of the chemistry and biology of ATP in particular within the cardiomyocyte is gifted. New insights into ATP were gleaned utilizing biophysical ideas permitting dynamic size of chemical occasions within the intact beating middle and utilizing new animal types during which cardiac proteins are both over expressed, deleted or harbor particular mutations.

This booklet offers a precis of the fundamental knowing and comprises illustrations of why ATP and the Heart is critical to either the clinician and scientist.

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Example text

In addition, resonances for phosphodiesters (POE; mainly membrane phospholipids) and 2, 3-diphosphoglycerate (OPG; resulting from blood contamination) are seen. Typically, spectra are quantified using the area ratio of PCr and ATP (PCr/ATP ratio), which is an index of the energetic state of the heart. ISIS localisation, TR = 2 RR intervals, adiabatic pulses. Number of averages 1024. Courtesy of Dr. S. Neubauer, University of Oxford. 45 ATP and the Heart • pH (intra- and extracellular pH and, under some conditions, mitochondrial pH).

All cells, but in particular excitable cells such as myocytes, maintain constant steady state ATP levels by matching ATP synthesis and utilization. The metabolic machinery needed to accomplish this formidable task without allowing the ATP concentration to fall is impressive. How this occurs is the subject of Chapters 9-11. 5 Relationships among [ATP] , ATP synthesis estimated from myocardial 02 consumption (MV0 2) and cardiac work estimated as the rate pressure product (RPP) in the isolated perfused rat heart.

How do we use ~G-ATP values to understand the physiology and pathophysiology of the heart? In order to know whether the driving force for the ATP-utilizing reactions is sufficient to allow the reaction to proceed, we compare the value of ~G-ATP calculated from estimates of the average cytosolic concentrations of ATP, ADP and Pi for the intact heart (the ideal calculation would use the values in the immediate vicinity of the ATPase) with the literature values for the ~G-ATP'S for the actomyosin ATPase and the sodium and calcium pumps.

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